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| Editor-in-Chief: Kuan-Teh Jeang Retrovirology is a stringently peer-reviewed journal edited by Kuan-Teh Jeang (USA), Monsef Benkirane (France), Ben Berkhout (the Netherlands), Masahiro Fujii (Japan),
Ariberto Fassati (UK), Michael Lairmore (USA), Andrew Lever (UK), and Mark Wainberg (Canada) with the assistance of an internationally renowned Editorial Board.
Read all the latest news from Retrovirology, on the Retrovirology blog
Latest supplementsVolume 7 Suppl 1
Meeting abstracts
Marseille, France. 24-26 March 2010
Latest articles
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Research
Broader HIV-1 neutralizing antibody responses induced by envelope glycoprotein mutants based on the EIAV attenuated vaccine
Lianxing Liu, Lan Wu, Huiguang Li, Xintao Hu, Jianping Sun, Liying Ma, Yanmin Wan, Haishan Li, Yiming Shao
Retrovirology 2010, 7:71 (1 September 2010)
[Abstract] [Provisional PDF]
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This study shows that an HIV envelope modified by the information of another lentivirus vaccine induces effective broadly neutralizing antibodies. A single amino acid mutation was found to increase the immunogenicity of the HIV Env.
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Research
Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors
Robert A Smith, Geoffrey S Gottlieb, A Dusty Miller
Retrovirology 2010, 7:70 (31 August 2010)
[Abstract] [Provisional PDF]
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The results indicate that specific 3'-azido or acyclic nucleoside analog inhibitors of HIV 1 reverse transcriptase (RT) also block XMRV infection with comparable efficacy in vitro. The data confirm that XMRV is highly resistant to the non-nucleoside RT inhibitors nevirapine and efavirenz and to inhibitors of HIV-1 protease. The integrase inhibitors raltegravir and elvitegravir are active against XMRV, with EC50 values in the nanomolar range.
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Research
An N-terminally truncated envelope protein encoded by a human endogenous retrovirus W locus on chromosome Xq22.3
Christina Roebke, Silke Wahl, Georg Laufer, Christine Stadelmann, Marlies Sauter, Nikolaus Mueller-Lantzsch, Jens Mayer, Klemens Ruprecht
Retrovirology 2010, 7:69 (24 August 2010)
[Abstract] [Provisional PDF] [PubMed] [Related articles]
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A partially defective HERV-W env gene located on chromosome Xq22.3 has retained coding capacity and can produce ex vivo an N-terminally truncated Env protein, named N-Trenv. Detection of an antigen by 6A2B2 in placenta and multiple sclerosis lesions opens the possibility that N-Trenv could be expressed in vivo. The findings are compatible also with the idea that defective HERV elements may be capable of producing incomplete HERV proteins that, speculatively, may exert functions in human physiology or pathology.
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Research
Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies
Xiaoxing Qiu, Priscilla Swanson, Ka-Cheung Luk, Bailin Tu, Francois Villinger, Jaydip Das Gupta, Robert H Silverman, Eric A Klein, Sushil Devare, Gerald Schochetman, John Hackett Jr
Retrovirology 2010, 7:68 (17 August 2010)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]
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Three rhesus macaques were infected with XMRV to determine the dynamics of the antibody responses elicited by infection with XMRV. All macaques developed antibodies to XMRV during the second week of infection, and the predominant responses were to the envelope protein gp70, transmembrane protein p15E and capsid protein p30. In general, antibody responses to gp70 and p15E appeared early with higher titers than to p30, especially in the early period of seroconversion. Antibodies to gp70, p15E and p30 persisted to 158 days and were substantially boosted by re-infection, thus, were identified as useful serologic markers.
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Editorial
Intelligence and ambition are distributed equally around the globe
Kuan-Teh Jeang
Retrovirology 2010, 7:67 (13 August 2010)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]
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The impact of freely accessible knowledge distribution platforms is briefly discussed.
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Short report
Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells
Nidhanapati K Raghavendra, Nikolozi Shkriabai, Robert LJ Graham, Sonja Hess, Mamuka Kvaratskhelia, Li Wu
Retrovirology 2010, 7:66 (11 August 2010)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]
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To efficiently identify additional host factors associated with PICs in infected cells, catalytically active PICs from HIV-1-infected CD4+ cells were isolated using biotinylated target DNA, and the proteins selectively co-purifying with PICs have been analyzed by mass spectrometry. This technology revealed at least 19 host proteins that are associated with HIV-1 PICs, of which 18 proteins have not been described previously with respect to HIV-1 integration.
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Research
Structural features in the Rous sarcoma virus RNA stability element are necessary for sensing the correct termination codon
Johanna B Withers, Karen L Beemon
Retrovirology 2010, 7:65 (5 August 2010)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]
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Nonsense-mediated mRNA decay (NMD) is an mRNA quality control mechanism that selectively recognizes and targets for degradation mRNAs containing premature termination codons. In the case of the Rous sarcoma virus (RSV), a stability element (RSE), which resides immediately downstream of the gag termination codon and facilitates NMD evasion was identified, and the key RNA features this RSE were characterized.
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Short report
Murine leukemia virus RNA dimerization is coupled to transcription and splicing processes
Stéphan Maurel, Marylène Mougel
Retrovirology 2010, 7:64 (5 August 2010)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]
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For the first time, it is reported that splicing and RNA dimerization appear to be coupled. The results indicate that randomness of heterodimerization increases when RNAs are co-expressed during either transcription or splicing. They strongly support the notion that dimerization occurs in the nucleus, at or near the transcription and splicing sites, at areas of high viral RNA concentration.
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Short report
No evidence for XMRV association in pediatric idiopathic diseases in France
Eric Jeziorski, Vincent Foulongne, Catherine Ludwig, Djamel Louhaem, Gilles Chiocchia, Michel Segondy, Michel Rodière, Marc Sitbon, Valérie Courgnaud
Retrovirology 2010, 7:63 (2 August 2010)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]
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Using a XMRV env-nested PCR, 72 DNA samples obtained from 62 children hospitalized in the Montpellier university hospital (France) for hematological, neurological or inflammatory pathologies, 80 DNA samples from nasopharyngeal aspirates from children with respiratory diseases and 19 DNA samples from SpA were screened. None of the samples tested was positive for XMRV or MLV-like env sequences, indicating that XMRV is not involved in these pathologies.
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Research
Functional interaction between Env oncogene from Jaagsiekte sheep retrovirus and tumor suppressor Sprouty2
Ebenezer Chitra, Yi-Wen Lin, Fabian Davamani, Kuang-Nan Hsiao, Charles Sia, Shih-Yang Hsieh, Olivia L Wei, Jen-Hao Chen, Yen-Hung Chow
Retrovirology 2010, 7:62 (2 August 2010)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]
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JSRV Env induced the expression of a tumor suppressor, Sprouty2, suggesting a correlation between them. Overexpression of Sprouty2 per se not only decreased the migratory potential and tumor formation potential of the target cells but also made them resistant to subsequent Env-mediated transformation. Conversely, the functional mutants of Sprouty2 had no inhibitory effect, confirming the role of Sprouty2 as a tumor suppressor.
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